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Journal of Ayurveda and Integrative Medicine Journal of Ayurveda and Integrative Medicine
 
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   2010| July-September  | Volume 1 | Issue 3  
    Online since November 20, 2010

 
 
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REVIEW ARTICLE
Ayurveda-modern medicine interface: A critical appraisal of studies of Ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis
Arvind Chopra, Manjit Saluja, Girish Tillu
July-September 2010, 1(3):190-198
DOI:10.4103/0975-9476.72620  PMID:21547047
The potential of Ayurvedic philosophy and medicines needs to be recognized and converted into real life treatment paradigm. This article describes a comprehensive therapeutic approach used in Ayurveda and modern medicine to treat arthritis. We present concise summary of various controlled drug trials carried out by us to validate standardized Ayurvedic drugs using modern medicine protocol to treat Rheumatoid Arthritis and Osteoarthritis knees. Several of the latter are published. The trials consistently demonstrate excellent safety of Ayurvedic medicines but often fail to unequivocally show superior efficacy. Some key findings of a recently unpublished trial in OA knees are also presented to show equivalence between Ayurvedic medicine and celecoxib and glucosamine, and we speculate that equivalence trials may be a way forward. The data from the trials also supports the Ayurvedic 'Rasayana' concept of immune-modulation and healing. We need to interpret logic of Ayurveda when, adopting modern science tools in drug development and validation and much research is required. Validation of Ayurvedic medicines using the latter approach may lead to an evidence based Ayurveda - Modern Medicine interface. Also, in pursuit of finding better treatment solutions, we ought to step beyond the realm of only drugs and attempt validation of comprehensive specific treatment package as per classical Ayurveda. Finally, validation of a combined (Ayurveda and modern medicine) therapeutic approach with superior efficacy and safety is likely to be a major leap in overcoming some of the current frustrations to treat difficult disorders like arthritis using only modern medicines.
  7,392 1,175 12
GENERAL ARTICLE
Health traditions of Sikkim Himalaya
Ashok Kumar Panda, Sangram Misra
July-September 2010, 1(3):183-189
DOI:10.4103/0975-9476.72617  PMID:21547046
Ancient medical systems are still prevalent in Sikkim, popularly nurtured by Buddhist groups using the traditional Tibetan pharmacopoeia overlapping with Ayurvedic medicine. Traditional medical practices and their associated cultural values are based round Sikkim's three major communities, Lepcha, Bhutia and Nepalis. In this study, a semi-structured questionnaire was prepared for folk healers covering age and sex, educational qualification, source of knowledge, types of practices, experience and generation of practice, and transformation of knowledge. These were administered to forty-eight folk healers identified in different parts of Sikkim. 490 medicinal plants find their habitats in Sikkim because of its large variations in altitude and climate. For 31 commonly used by these folk healers, we present botanical name, family, local name, distribution, and parts used, together with their therapeutic uses, mostly Rheumatoid arthritis, Gout, Gonorrhea, Fever, Viral flu, asthma, Cough and Cold, indigestion, Jaundice etc. A case treated by a folk healer is also recounted. This study indicates that, in the studied area, Sikkim's health traditions and folk practices are declining due to shifts in socio-economic patterns, and unwillingness of the younger generation to adopt folk healing as a profession.
  5,757 424 1
CLINICAL
Ankylosing spondylitis
Mukesh Edavalath
July-September 2010, 1(3):211-214
DOI:10.4103/0975-9476.72619  PMID:21547050
Ankylosing spondylitis belongs to a group of rheumatic diseases known as the spondyloarthropathies (SpA), which show a strong association with the genetic marker HLA-B27. Inflammatory back pain and stiffness are prominent early in the disease, whereas chronic, aggressive disease may produce pain and marked axial immobility or deformity. Modern medicine has no established treatment for it. From the Ayurvedic perspective, the disease can fall under amavata, which may be effectively managed when intervention is started in its early stages. Niruha basthi with Balaguduchyadi yoga, combined by Shamana treatment with Rasnerandadi kwatha and Simhanada guggulu have been found effective in curbing its progression. This article presents a single case report in which these treatments achieved considerable success.
  5,293 760 -
EXPERIMENTAL
A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease
Sapna N Shetty, Sushma Mengi, Rama Vaidya, Ashok D. B. Vaidya
July-September 2010, 1(3):203-210
DOI:10.4103/0975-9476.72622  PMID:21547049
As a major organ of intermediary metabolism, the liver is exposed to a variety of metabolic insults due to diseases and xenobiotics viz., insulin resistance (IR) drugs, toxins, microbial products, etc. One of the consequences of these metabolic insults including obesity and type 2 diabetes mellitus is the development of non-alcoholic fatty liver disease (NAFLD). The recent alarming increase in the prevalence of NAFLD compels the need to develop an appropriate animal model of the disease so as to evolve effective interventions. In this study, we have developed, in the rat, a new model of NAFLD showing several key features akin to the disease in humans. Male Wistar rats were challenged with 30% high fat diet (HFD) - butter, for 2 weeks to induce NAFLD. A hydroalcoholic extract of Picrorhiza kurroa was administered to study the possible reversal of fatty changes in the liver. The extract was given in two doses viz., 200mg/kg and 400 mg/kg b.i.d., p.o. for a period of 4 weeks. There were three control groups (n = 6/group) - vehicle with a regular diet, vehicle with HFD, and HFD with silymarin - a known hepatoprotective. Histopathology showed that the P. kurroa extract brought about a reversal of the fatty infiltration of the liver (mg/g) and a lowering of the quantity of hepatic lipids (mg/g) compared to that in the HFD control group (38.33 ± 5.35 for 200mg/kg; 29.44 ± 8.49 for 400mg/kg of P. kurroa vs.130.07 ± 6.36mg/g of liver tissue in the HFD control group; P<0.001). Compared to the standard dose of the known hepatoprotective silymarin, P. kurroa reduced the lipid content (mg/g) of the liver more significantly at the dose of 400mg/kg (57.71 ± 12.45mg/kg vs. 29.44 ± 8.49 for the silymarin group vs. 400mg/kg of P. kurroa, P<0.001). In view of the increasing prevalence of metabolic syndrome and NAFLD, P. kurroa should be investigated by the reverse pharmacology path as a potential drug for the treatment of NAFLD, and essential safety studies and preformulation research for concentration of the putative actives should be carried out.
  4,256 749 6
CLINICAL
Herbo-mineral ayurvedic treatment in a high risk acute promyelocytic leukemia patient with second relapse: 12 years follow up
Balendu Prakash, Purvish M Parikh, Sanjoy K Pal
July-September 2010, 1(3):215-218
DOI:10.4103/0975-9476.72618  PMID:21547051
A 47 year old diabetic male patient was diagnosed and treated for high risk AML-M3 at Tata Memorial Hospital (BJ 17572), Mumbai in September 1995. His bone marrow aspiration cytology indicated 96% promyelocytes with abnormal forms, absence of lymphocytic series and myeloperoxide test 100% positive. Initially treated with ATRA, he achieved hematological remission on day 60, but cytogenetically the disease persisted. The patient received induction and consolidated chemotherapy with Daunorubicin and Cytarabine combination from 12.01.96 to 14.05.96, following which he achieved remission. However, his disease relapsed in February 97. The patient was given two cycles of chemotherapy with Idarubicine and Etoposide, after which he achieved remission. His disease again relapsed in December 97. The patient then refused more chemotherapy and volunteered for a pilot Ayurvedic study conducted by the Central Council for Research in Ayurveda and Siddha, New Delhi. The patient was treated with a proprietary Ayurvedic medicine Navajeevan, Kamadudha Rasa and Keharuba Pisti for one year. For the subsequent 5 years the patient received three months of intermittent Ayurvedic treatment every year. The patient achieved complete disease remission with the alternative treatment without any adverse side effects. The patient has so far completed 13 years of survival after the start of Ayurvedic therapy.
  2,636 369 4
LIFE PROFILE
Vaidya V. B. Mhaiskar
Vaidya Narendra M Pendse
July-September 2010, 1(3):219-221
DOI:10.4103/0975-9476.72616  PMID:21547052
  1,795 225 -
EXPERIMENTAL
Antioxidant and antifungal activities of essential oil of Alpinia calcarata Roscoe rhizomes
Lakshmi S.R Arambewela, L.D.A. Menuka Arawwawala, Nandakumara Athauda
July-September 2010, 1(3):199-202
DOI:10.4103/0975-9476.72621  PMID:21547048
Antioxidant and antifungal activity were determined for the essential oil of Alpinia calcarata Roscoe (Zingiberaceae) rhizomes. Its antioxidant properties were investigated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Butylated hydroxy toluene (BHT) and vitamin E served as positive controls. Antifungal activities were investigated against crop pathogens Curvularia spp. and Colletorichum spp. using the agar plate method. Fifty percent effective concentration (EC 50 ) and % antioxidant index of the essential oil were 45 ± 0.4 and 16.1 ± 0.2 for DPPH and TBARS assays, respectively. The degree of, the essential oil's inhibition of the growth of crop pathogens Curvularia spp. and Colletorichum spp. varied with time period its effects were higher than greater than for the positive control, daconil. In conclusion, the essential oil of A. calcarata rhizomes possess moderate antioxidant property and promising antifungal activity.
  1,647 362 5
INITIATIVES
Ayurveda in Argentina and other Latin American countries
Jorge Luis Berra, Rosana Molho
July-September 2010, 1(3):225-230
DOI:10.4103/0975-9476.72614  PMID:21547054
Over the past 20 years the Fundacion Salud de Ayurved Prema Argentina has spread the knowledge of Ayurveda throughout Latin America. The Fundacion is based in Buenos Aires in the Argentine Republic, where it now runs courses in two of the country's major medical schools - at the School of Medicine of the University of Buenos Aires, and the National University of Cordoba's School of Medicine. Based on an MoU with Gujarat Ayurveda University, at Jamnagar, Gujarat, the Fundacion has been accredited as a Collaborating Center for teaching, assistance and research in the field of Ayurvedic Medicine in Argentina. This has led to successful missions to other countries in the region where the Fundacion and its associates have been able to start dialogues with governments, and in places hold sizeable courses. The knowledge of Ayurveda is now spreading throughout South and Central America and hardly a country remains untouched by it.
  1,238 204 -
THOUGHT LEADERSHIP ARTICLE
Seeing with two eyes: How professionals can help patients trying to integrate medical systems
AV Balasubramanian
July-September 2010, 1(3):177-182
DOI:10.4103/0975-9476.72613  PMID:21547045
  1,112 240 1
LETTERS TO THE EDITOR
How practical are the "teaching reforms" without "curricular reforms"?
Kishor Patwardhan
July-September 2010, 1(3):174-176
DOI:10.4103/0975-9476.72612  PMID:21547044
  1,105 204 1
Validation of Ayurvedic formulations in animal models requires stringent scientific rigor
SC Lakhotia
July-September 2010, 1(3):171-172
DOI:10.4103/0975-9476.72607  PMID:21547041
  964 294 2
EDITORIAL
Ayurveda, evidence-base and scientific rigor
Bhushan Patwardhan
July-September 2010, 1(3):169-170
DOI:10.4103/0975-9476.72605  PMID:21547040
  844 366 3
VIGNETTE
Balaraj Maharishi and the first clinical trial of Ayurvedic medicines in the West
Donn Brennan
July-September 2010, 1(3):222-224
DOI:10.4103/0975-9476.72615  PMID:21547053
  1,015 172 -
LETTERS TO THE EDITOR
Model organisms in Ayurvedic research
Madan Thangavelu
July-September 2010, 1(3):173-174
DOI:10.4103/0975-9476.72610  PMID:21547043
  844 239 -
BOOK REVIEW
Insights into Ayurveda
Pulok K Mukherjee
July-September 2010, 1(3):231-232
  638 221 -
LETTERS TO THE EDITOR
Authors' reply
S Priyadarshini, JS Ashadevi, V Nagarjun, KS Prasanna
July-September 2010, 1(3):172-173
PMID:21547042
  643 171 -
NEWS AND COMMENT
India and South Africa to cooperate on research on traditional medicine
Alex Hankey
July-September 2010, 1(3):234-234
  626 169 -
FUTURE EVENTS
Future Events

July-September 2010, 1(3):235-236
  624 134 -
OBITUARY
Dr. Rustum Roy (1924-2010)
Dilip Mehta
July-September 2010, 1(3):233-233
  595 127 -
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